Preheat oven to 450 degrees. Line a sheet pan with foil and spray with non-stick cooking spray. (I used a cooling rack to get brussels sprouts evenly cooked on every side, and sprayed this with cooking spray as well). Microwave brussels sprouts in bag (or in bowl covered with saran wrap, pierced with a knife to let steam out) for 5 minutes.
Place brussels sprouts on prepared pan and spray with cooking spray, (this helps seasonings to stick). Season with salt, pepper, and garlic and onion powder. Divide parmesan cheese evenly over brussels sprouts.
Roast brussels sprouts for 12-15 minutes, or until parmesan cheese becomes lightly golden brown. (I broiled mine for the last minute to ensure the parmesan cheese gets nice and golden!) Remove from the oven and drizzle honey evenly over brussels sprouts and enjoy!